Efficacy Of Hyaluronic Acid And Corticosteroid Intra-Articular Injection In Knee Joint With Primary Osteoarthritis


Background: Osteoarthritis OA is the most common joint disorder in the world. Injection of high molecular weight hyaluronic acid intra-articular with steroid is a one of the used therapeutic option for patients with (OA)knee. Objectives: Objective of this study was the evaluation the efficacy, safety, pluse duration of action of viscosupplementation of the HMWHA( high molecular weight hyluranic acid ).Type of the study: Cross-sectional study.Methods: From 81 patients with sever knee pain due to OA (grades 3–4) were recruited from Al-Yarmouk teaching hospital & a private clinic during the period from January 2014 till July 2016. The patients were (24 males - 57 females) with mean age 57.14 years( range from 45y -64 y). Visual Analog Scale (VAS) questionnaire for pain, morning stiffness calculated by minuets and physical function were used to assess treatment efficacy after intra-articular HMWHA injection.Results: The study included 81 patients who gave the examination data and complete the vital baseline and follow-up data necessary to check for the safety and efficacy .Major improvement was seen after 6 months from injection, as pain, stiffness and physical activity data decreased to 20.32, 1.42 and 4.44 respectively. Such achievement continue for 9 months after injection, as the pain marks was 28.3, the stiffness marks was 3.15,while the physical activity marks was 5.Conclusions: injection of HMWHA with steroid intr articular is effective, safe for the period of 9 months for those patients who complain from moderate and severe OA knee joint.