Immune Profile in Aborted Iraqi Women with Toxoplasmosis
Abstract
Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcomeof such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women withtoxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linkedimmunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulatingfactor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-ɣ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levelsof C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-ɣ showedsignificant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groupsof the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite inescaping from discrimination and elimination by the immune system then supporting its survival and replication.
Keywords
Abortion, adaptive immune response, innate immune response, single radial immune diffusion, toxoplasmosisMetrics