The Value of C- Reactive Protein in Neonatal Sepsis


Abstract:Background: Neonatal sepsis occur 1-8 per 1000 live birth. It is mandatory to have a high index of suspicion for the possibility of sepsis since the signs and symptoms are non specific. (C-Reactive Protein) CRP an acute phase protein used as a screening test for inflammation and disease activity and diagnostic adjuvant. Objective: To evaluate the importance of CRP in the diagnosis of neonatal sepsis, sensitivity, specificity and the predictive value of it.Patients &methods: One hundred neonates with suspected sepsis were admitted to the Central Teaching Hospital for Children / Baghdad, between 1st of April and 1st of October 2005, were selected for diagnosis of sepsis by CRP and blood culture. The clinical presentations of these neonates were studied to find the most common signs and symptoms.Results: there were 76% of total cases with positive CRP . 53% of cases had positive blood culture and CRP, and the sensitivity was 96.36%, specificity was 48.8% and the negative predictive value was 91.6% and the positive predictive value was 69.7% Conclusions: CRP show high sensitivity and negative predictivevalue which are helpful in the diagnosis of sepsis. A singlenormal value cant exclude infection and serial measurements will enhance the sensitivity of the test. CRP is not recommended as a sole indicator of neonatal sepsis but may be one of a septic work up.