STUDY THE EFFECT OF SOME BIOCHEMICAL CHANGES IN SEMINAL FLUID OF PATIENTS WITH OLIGOSPERMIA

Abstract

The aim of the present study is to investigate the role of chemical changes of the seminal fluid in thefertility of oligospermic men. We evaluated the role of spermatozoal creatine kinase enzyme and seminalplasma alkaline phosphatase, Acid phosphatase, total protein, albumin, uric acid, calcium, chloride, inorganicphosphate, createnine and fructose in oligospermic patients and their relation to sperm count andactivity in 62 individuals ( 42 infertile oligospermic, and 20 normal fertile volunteers) , and wesubdivided the oligospermia to three subgroups (Mild ,Moderate, Severe Oligospermia).Results: Creatine kinase:-there was a significant increase in the spermatozoal CK in the oligospermic groupas compared to normal group there was a significant increase in CK levels with decreasing motility.Alkaline phosphatase (ALP): there was a significant decrease in ALP activity in the oligospermia ascompared to normal group, but no change observed related to motility.Fructose: there was a significant increase in the level of seminal plasma fructose in oligospermic group ascompared with normospermic. Within the oligosoermic group and there was a negative correlation betweenfructose concentration and motility.There was no significant change observed in Acid phosphatase, Total protein, albumin Uric acid, Calcium,Chloride, Inorganic phosphate and Createnine.