SYNTHESIS OF SOME NEW DRUG DELIVERY POLYMERS THROUGH IMINE GROUP AND STUDYING THEIR IN VITRO RELEASE.

Abstract

ABSTRACT:[A,B and C] Contains formyl group were synthesized through the condensationpolymerization of [Ortho, Meta, Para] – hydroxyl benzaldehyde with formalin in basic medium. Theprepared polymers were reacted with different drugs containing amino groups [ Aldomet , Isonizide ,Sulfamethoxazole ,Folic acid ] through condensation reaction to gives twelfth new polymers. Thestructures of these polymers were characterized using [ IR, U.V] spectral data, the result obtained arecompared with their assigned structures.The prepared polymer conjugated supported drugs werestudied for controlled drug release in- vitro at following pH [7.3, 9.4, 1.2] and at constant temperature[25C ◌ْ ] . The obtained result indicate that the polymer structure and pH media have a significanteffects on controlled drug release .