Preparation and identification of some a new derivative for Trimethoprim drug


In this reaction new derivatives for Ttrimetheprim compound, which have high medicinal effectiveness, was prepared by the interaction of its coupling diazonium salt with some substituted phenol compounds (2-naphthol , 4-bromo phenol, 2,5-dimethoxy phenol ,2,4-dinitro phenol , 3-chloro phenol.Chemical structures of all products were confirmed by photometric methods such as U.V. visible and FTIR.The biological activities was also examined for these compounds.Gram + ve bacteria (bacillus) , Gram –ve bacteria (E-Coli) and fungi (Aspiringussb).