Evaluation of Serum Sialic Acid and Protein Associated Sialic Acid In Premature Low Birth Weight Neonates

Abstract

Objective: In a pioneer study conducted in Iraq, the serum levels of sialic acid and protein associated sialic acid were tested to evaluate their level in premature low birth weight (LBW) neonates The study was conducted in Tikrit Teaching Hospital during the period from the 1st of February 2006 till the 1st of July 2007.
Material & Methods: The study had been done on 300 neonates; they were divided into 4 groups, and these includes 100 apparently healthy normal birth weight mature neonates (NBW), 100 apparently healthy low birth weight premature neonates (LBW), 50 low birth weight premature neonates with birth asphyxia (LBW+BA), and 50 low birth weight premature neonates with respiratory distress syndrome (LBW+RDS).
The following biochemical parameters were measured in sera of the studied neonates and the control groups which included: total sialic acid (TSA) and protein associated sialic acid (PASA).
Results: Revealed that: there is a significant statistical difference between the NBW and the LBW neonates regarding the birth weight and the gestational age while there is no significant difference concerning the age of the newborns. Also there is a significant statistical difference between the LBW neonates and the LBW+BA and LBW+RDS neonates regarding the gestational age, age, and birth weight. The mean serum level of TSA is lower in the LBW in comparison with the NBW. It is also found that the mean value is significantly higher in LBW+BA and LBW+RDS in comparison with LBW and NBW neonates. It is also evident that the mean serum value in LBW+BA is significantly higher than that in LBW+RDS. Serum TSA levels are correlated strongly and positively with serum PASA levels in LBW neonates and LBW+BA and in LBW+RDS .
In conclusion; the mean serum sialic acid and protein associated sialic acid level was found to be significantly higher in LBW+BA and LBW+RDS in comparison with premature LBW and NBW neonates.