Polycystic Ovary Syndrome and related Some Genetic Markers


AbstractPolycystic ovary syndrome (PCOS) is the most familiar endocrine disorder affecting women ofchildbearing could be happen with problem and metabolic anomalies. PCOS women present withovulatory dysfunction, abnormal hormones, hyperandrogenemia, obesity, and hyperinsulinemia.Patients with PCOS may present complaining of irregular or unpredictable menstrual cycles,undesirable hair growth, acne , scalp hair loss, unexplained weight gain or overweight,and infertility.Clinical phenotyping of PCOS involves determining medical and/or biochemical androgen excess. Thebulk of evidence points to the ovary being the source of excess androgens, which appears as a resultof an abnormal regulation of steroidogenesis.It is a heterogeneous disorder which results from interaction of multiple genes and environmentalfactors.