Oxidative stress marker malondialdehyde and antioxidants superoxide dismutase and uric acid in ischemic heart disease patients

Abstract

ABSTRACT
Background: When the oxidant-antioxidant balance is disturbed in favour of reactive oxygen species (ROS),
oxidative stress occurs, which is damaging to tissues. Oxidative stress and ROS have been reported to be related to
the pathogenesis of many diseases including ischemic heart diseases. The aim of this study was to assess oxidative
stress marker malondialdehyde (MDA) and the antioxidants uric acid (UA) and superoxide dismutase (SOD) in serum
and saliva of ischemic heart diseased patients.
Materials and Methods: Eighty subjects were enrolled in this study, forty patients were diagnosed as ischemic heart
disease (IHD), their ages ranged between 42-80 years, and forty individuals were age and sex matched healthy
looking volunteers. MDA, UA and SOD have been estimated for all the serum and salivary samples.
Results: The mean levels of serum and salivary MDA, UA, and SOD in IHD patients were higher than that of healthy
controls. Age was the most important explanatory factor that affects salivary MDA, UA, and SOD.
Conclusions: Ischemic heart disease patients are associated with increased oxidative stress which has been
represented by increased MDA levels and increased antioxidants UA and SOD in serum and saliva.
Key words: Ischemic heart diseases, oxidative stress, malondialdehyde, superoxide dismutase, uric acid. (J Bagh Coll
Dentistry 2009; 21(4):65-71)