Oxidative stress in relation to two different pathologies in metabolic syndrome patients


Background and objective: Little is known about the status of redox balance and hypertensive nondiabetic and diabetic nonhypertensive metabolic syndrome patients and its relation to metabolic syndrome components in both pathological conditions. This study aimed to assess the association of redox balance with components of metabolic syndrome in "diabetic and hypertensive, metabolic syndrome" patients to find out which pathology can give a powerful evidence for a possible association with oxidative stress.Methods: The total oxidative capacity, total antioxidant capacity, lipid profile and fasting serum glucose were measured in serum of 35 healthy subjects, 33 hypertensive nondiabetic and 21 diabetic nonhypertensive, metabolic syndrome patients. The body mass index and waist circumference were also measured. All groups were age and gender matched.Results: In stratified groups, the highly significant total oxidative capacity, total antioxidant capacity and oxidative stress index were shown in diabetic and hypertensive groups respectively compared with healthy control group, with no significant effect for diabetes on total oxidative capacity and oxidative stress index compared to hypertension condition.Conclusion: Although the presence of significant higher total oxidative capacity in both study pathologies compared to healthy control, however among metabolic syndrome patients neither hypertension nor diabetes mellitus achieved more dominant to total oxidative capacity.