Study of IL-33 and IL-1R4 in Iraqi Rheumatoid Arthritis Female Patient's with and without Dyslipidemia Prone to Atherosclerosis

Abstract

This study is planned to find relationship between interleukin-33 (IL-33) with its receptorinterleukin-1 receptor 4 (IL-1R4), and assurance IL-33/IL-1R4 proportion as biomarker toatherosclerosisin rheumatoid arthritis (RA) Iraqi female’s patients with and withoutdyslipidemia. This study was attempted at Baghdad Teaching Hospital included 60 female’spatients with RA that were isolated into: 30 patients with dyslipidemia(G2), 30 patientswithout dyslipidemia(G3) and 30 individuals as control group (G1). Patients wereexperiencing treatment by methortexiene medication, analyzed by rheumatoid factor (RF) anderythrocyte sedimentation rate (ESR) tests. All patients and control groups age ranged from(30-55) years. The results show an increase in ESR, RF, IL-33, and IL-1R4 levels. In additionto decrease in IL-33/IL-1R4 ratio in the two patient’s groups when contrasted and controlgroup. The momentum examine inferred that the level of ESR, and IL-33 in RA Iraqi femalespatients with dyslipidemia were higher than that in RA Iraqi females patients withoutdyslipidemia, while the level of IL-33/IL-1R4 ratio in RA Iraqi females patients withdyslipidemia was lower than that in RA Iraqi females patients without dyslipidemia patients;in this manner the IL-33/IL-1R4 ratio may be used as a biomarker in diagnostic early porn toatherosclerosis in RA females patients with dyslipidemia.