Evaluation of serum srace element levels in children with bronchial asthma

Abstract

Background and objectives: The metabolism of several trace elements has been reported to alter in bronchial asthma and these elements might have specific roles in the pathogenesis and progress of this disease. The aim of the present study was to investigate serum levels of Zinc, Copper, Calcium, Iron and Magnesium in asthmatic childrenPatients and Methods: The comparative study includes 56 asthmatic patients and 44 healthy non asthmatic control subjects. The trace elements concentrations were measured by means of an atomic absorption spectrophotometer, results were calculated from the calibration curve obtained by statistical analysis of concentration Vs Absorbance data for elements using fitting of straight line by least square.Results: Mean(±SD) zinc level was significantly (p<0.01) decreased in asthmatic children (70.6±8.3 μg /dL) compared with controls non asthmatic children (78.3± 9.2 μg /dL),calcium and iron serum concentrations were significantly(p<0.001) higher in asthmatic patient (10.98±2.53 mg/dL, (113.23 ± 45.47 μg/dl) respectively compared with controls (8.23±3.4mg/dL,83.25±29.43 μg /dL) respectively, on the other hand copper level was significantly (p<0.01) higher in asthmatic children (143±20.8μg/dl) in comparison to the control values (130±22.7 μg/dL). Magnesium concentration was significantly lower in comparison to the control values (p<0.01).Conclusion: The results support that deficiency of Mg, Zn, Cu, Ca and Fe may play a role in the development of asthma.