A new insight in the role of serum albumin and albumin binding capacity for cobalt and copper in ischemic heart disease


Background and Objectives: In the presence of ischemia, albumin, undergoes changes resulting in the formation of ischemia modified albumin .Increased serum concentration of ischemia modified albumin that was measured by albumin cobalt binding assay have been found in patients with myocardial ischemia. The purpose of this study was to investigate the relationship between serum albumin concentration and ischemia modified albumin concentration.Methods: Eighteen patients with stable angina and fifteen who didn’t have any evidence of coronary artery disease , were taken as control subjects, both groups underwent treadimall exercise stress test ,about 15 minuets after treadimall test blood samples were drawn from all the subjects, brought to laboratory to measure the serum ischemia modified albumin concentration and serum albumin concentration.Results: The study showed a significant difference in ischemia modified albumin between study groups, while no significant difference in serum albumin between both groups. There is a largest Receiver Operating Characteristics(ROC) area for ratio of serum albumin cobalt binding to serum albumin than serum albumin cobalt binding capacity alone.There is a weak positive linear correlation for both cupper and cobalt binding capacity among control subject ,where there is a weak negative linear correlation for both markers among cases with ischemic heart disease (IHD).Conclusion: The quantification of the role of serum albumin in combination with albumin cobalt binding capacity is expected to differentiate between ischemic heart disease patient and normal subject to larger extent.