Evaluation of Serum Level of Soluble Lectin‑like Oxidized Low‑density Lipoprotein Receptor‑1 and its Relationship with Severity of Preeclampsia and Birth Weight

Abstract

Background: Lectin‑like oxidized low‑density lipoprotein receptor‑1 (LOX‑1) is one of the pattern recognition receptors that plays a critical rolein vascular diseases and host immune response, LOX‑1 can induce endothelial dysfunction through pathways implicated with oxidative stress andinflammation that ends with vascular lesions. Objective: The objective of the study is to evaluate the serum level of soluble LOX‑1 (sLOX‑1)in preeclampsia (PE) and normal pregnancy to study its relationship with the severity of PE and birth weight. Materials and Methods: A totalof 56 patients with PE were allocated to the study together with 28 healthy pregnant women as normal controls. PE patients divided into 28mild and 28 severe PE. Levels of serum sLOX‑1 were measured by sandwich enzyme‑linked immunosorbent assay technique. Results: Resultsshowed a significant increase in the serum sLOX‑1 in preeclamptic patients (P < 0.01) compared to normal controls. The significance increasedin serum levels of sLOX‑1, was noted in mild (P = 0.001) and severe patients (P = 0.001), compared to normal controls. There was a significantdecrease in fetal birth weight in severe PE as compared to mild and control groups which was correlated with sLOX‑1, furthermore, logisticregression of the variables for the presence of low birth weight <2.5 kg. Conclusion: High level of serum sLOX‑1 is associated with theoccurrence and severity of PE, which provides additional information for predicting of PE and preventing its complications and for betterunderstanding pathogenesis of PE and the results highlight the involvement of innate immunity molecules and inflammation in pathogenesisof PE through binding to apoptotic cells and angiogenic process.