Some Anatomical and Histological effects of Diclofenac Sodium to the Stomach, Kidney and Liver in rats.

Abstract

Diclofenac sodium (DS) is one of Non-steroidal anti-inflammatory drugs (NSAIDs).It is commonly used to relief pain and treats several disorders like renal diseases, inflammation and fever. This study was designed to show the effects of over dose of diclofenac sodium75ml/kg B.W in 5 days anatomically and histologically to the stomach, kidney and liver. 24 experimental rats were used,femal ages range between 8-10 weeks. The anatomical change include increase weight and grossly change in surface of these organs and mucosa of stomach but histological change in these tissue include damages which can form mucosal erosions in stomach. However, in kidney it causes infraction in the same area of cortex. Moreover, medulla causes congestion, and in liver occur hepatocyte inflammation and increase fibrous tissue.