HYPERURICEMIA AMONG PATIENS WITH METABOLIC SYNDROME ATTENDING DUHOK DIABETES CNTER

Abstract

Background and objectives Hyperuricemia is known to be associated with type2 Diabetes Mellitus (type 2 DM) and metabolic syndrome. However, this association still needs to be delineated in our population .The aims of this study were to evaluate the prevalence of hyperuricemia in Kurdish type 2 DM population and to explore the metabolic factors clustering with hyperuricemia for patients with metabolic syndrome.Methods Across-sectional study was conducted on 400 patients with metabolic syndrome .They were selected from patients diagnosed as type 2 DM or being treated with antidiabetic drugs who visited Duhok Diabetes Center during the period of the study(n=3678).The patients were divided into quartile according to their uric acid levels, lowest(first) quartile to the highest(fourth) quartile. The metabolic syndrome was defined according to the ATP-111 criteria; we exclude patients treated for hyperuricemia.Results The prevalence of hyperuricemia was 8.0% .The age prevalence of hyperuricemia was 5.8% in the patients aged 40-60 years and 2.2% in those aged more than 60 years .The mean serum uric acid was 4.98 mg/dl(95%Cl 4.79-5.15) for males and 4.18 mg/dl (95%Cl 4.01-4.35) for females. In ANOVA analysis, patients with first quartile (uric acid< 4.0 mg/dl)were associated with lower mean values of waist circumference, blood pressure, triglycerides, blood glucose, insulin and HOMA-IR; but higher values of HDL-cholesterol than those with this comorbidity. A significant correlation between serum uric acid and insulin resistance wasobserved(r=0.344, p=0.01), and a less significant value with waist circumference(r=0.125, p<0.05) and triglycerides (r=0.206, p<0.05).Conclusions In patients with metabolic syndrome, about half have uric acid levels (>4.0 to <7.0 mg/dl) and one out of 10 has hyperuricemia. The most determinant of hyperuricemia is waist circumference and insulin resistance.