The effect of aqueous extract of green tea leavesinsome biochemical and hisological parameters of male rats treated with gentamicin.

Abstract

AbstractThis study is designed to investigate the effect of aqueous extract of green tea leaves in kidney andliver functionsand hisological changes. It carried out on 36 wister albino male rats,which divided intosix groups (each group 6 rats) and treated as following: first group which received normal saline (0.9NaCl)as control group,second and third groupsreceived green tea (100, 200 mg/kg) respectively.While fourth group injected by gentamicin (100 mg/kg i.p), fifth and sixth groups injected bygentamicin at the same dose above, then after one hour these groups (5 and 6) administered extract ofgreen tea at (100, 200 mg/kg) respectively, time of experment is 10 days, The results showed asignificant increase (P≤0.05) in levels of urea and createnine in gentamicin group compared withcontrol group and other groups, createnine increased significantly (P≤0.05) in sixth group comparedwith control group and third group (treated with extract of green tea 200 mg/kg) only. Results alsorevealed a significant increase (P≤0.05) in levels of Glutamic Oxaloacetic Transaminase(GOT) ingentamicin group compared with control group, in fifth group (GOT) increased significantly(P≤0.05) compared with second group (100 mg/kg) only, Glutamic pyruvic Transaminase(GPT)andAlkaline phosphatase (ALP)levels increased significantly (P≤0.05) in gentamicin groupand fifth group (gentamicine+ green tea 100 mg/kg) compared with control group and other groups.,also the different between these both groups was significantly (P≤0.05). Results of hisological studyconfirmedthe toxicity of gentamicinand protective effects of green tea leaves extract in kidney andliver.