Effect of Sertraline and Fluoxetine on Some Biochemical Parameters and Histological Changes in Male and Female Laboratory Rats Rattus norvegicus


Abstract:The current study was designed to determine the effect of sertraline and fluoxetine drugs on somebiochemicals and histologicals change of male and female rats. The animals were divided into five groups(each group consisting of 5 males and 5 females), the first group (control) was injected with thephysiological solution Nacl 0.9%, second group was injected with10 mg / kg of Sertraline, third group wasinjected with 20 mg / kg of sertraline, fourth group was injected with 5 mg / kg of fluoxetine and fifth groupwas injected with10 mg / kg fluoxetine. The results showed that a significant increase (P≤0.05) in theconcentration of urea and creatinine (except for the second group of females) in all treated group comparedwith control. In the liver enzymes, the results showed that a significant decrease in the concentrations ofaspartate transaminase enzyme, Alanine transaminase and alkaline phosphatase in all treated groupscompared with the control group(P≤0.05). The kidney tissue showed histological changes such asinfiltration of inflammatory cell, congestion, hemorrhage, renal glomerular distraction and loss, renaltubular hypertrophy.