Evaluation The Immune Status Of Blood Transfusion-Dependent Thalassemia In Thi-Qar Province/Iraq


Abstract: The present study was conducted at the Center of an inherited blood disorder in Dhi-Qar Province, during the period from October 2018 to January 2019. The aim of this study was to evaluate the immune status of patients with beta-thalassemia by measuring )IgM, IgG, IgA, C3 and C4( complement by used single radial immune diffusion (SRID. The study included a total of 150 patients with beta-thalassemia and included (66 males) and (84 females) and their age from (2 to 33 years). The patients divided into three age groups. The second age group( 11-20 ) years the most dominant. All patients over 20 years have been exposed to spleen removal operations. When compared with similar age groups of control groups consisting of 50 healthy persons, there was a significant increase of serum IgM, IgG, and IgA in all age groups of beta-thalassemia patients. The levels of serum IgG, IgM and IgA increased significantly with increased age in patients with beta thalassemia. The levels of C3 and C4 were significantly reduced in serum in all age groups of patients with beta-thalassemia except the first age group for C4 compared to similar age groups of healthy individuals.