The role of genetic polymorphism of glutathione -S transferase in cancer development and anticancer drug resistance

Abstract

Glutathione S-transferse family is an antioxidant enzymes. This family of proteins is characterized by enzymatic and non-enzymatic properties that have rendered them an important factor in many metabolic processes, including internal and external origin detoxification , cell proliferation, apoptosis, and drug resistance. The genetic polymorphisms in glutathione s- transferase affect the biologic activity of this enzyme and thus affect its role in the metabolic pathways that participates in it and make subjects vulnerable to many of the cancerous diseases that have been addressed here. In addition, genetic polymorphism of GST may affect on the response of the patients to anticancer drugs.