LIPID PROFILE IN SUBCLINICAL HYPOTHYROIDISM: A TWO CENTERS EXPERIENCE

Abstract

Background: Subclinical hypothyroidism (SCH) is estimated to affect around 7.5-8.5% of females and 2.8-4.4% of males. One of the features of clinical hypothyroidism is dyslipidemia. There is a great debate about the presence of abnormal lipid profiles in patients with subclinical hypothyroidism (SCH) and weather it is clinically significant or not. Some evidences show reduction in the level of the serum lipid profile after replacement with thyroid hormones. The purpose of this study is to estimate the prevalence of dyslipidemia in patients with subclinical hypothyroidism in Duhok and Erbil cities, Iraq.Patients and Methods: This is a case-control study that was done on 200 individuals. One hundred patients confirmed with subclinical hypothyroidism were compared with a group of 100 apparently healthy individuals. These two groups were matched for age and sex. The study done in 2 centres; Azadi Teaching Hospital in Duhok and Rizgari Teaching Hospital in Erbil, Kurdistan Region, Iraq from from 1st December 2017 to 1st December 2018. Results: Dyslipidemia was commoner in patients with subclinical hypothyroidism compared to control group (p value 0.001) compared to the control group (p value 0.766). The total cholesterol and the triglyceride levels were steadily increased in relation to the level of the thyroid stimulating hormone (TSH). Conclusions: Subclinical hypothyroidism (SCH) is regarded as an atherogenic condition because it increases the cholesterol and the triglyceride levels. Management of subclinical hypothyroidism with thyroid hormones may have a positive impact on the cardiovascular health. It is reasonable to measure the levels of the serum lipids and cardiovascular risk in these patients and to manage them when it is clinically applicable.