EFFECT OF TOPIRAMATE DRUG ON NEUROTRANSMITTERS LEVELS ( ACETYLCHOLINE AND DOPAMINE ) IN PREGNANT ALBINO RATS

Abstract

The present study aimed to elucidate the effect of Topiramate drug on neurotransmitters levels (Acetylcholine and Dopamine) in pregnant albino rats for different periods (7,9,12,14 and 21 days) of gestation.The present study was conducted on female albino rats (n = 40). Their weights arranged between (195 – 285 gm). The pregnant albino rats were divided into 5 groups, each group includes 8 pregnant rats and each group subdivided into control and treated (control =4 , treatment= 4).The control groups administrated orally distilled water (1 ml), while the treated group administrated Topiramate drug (100 mg/kg b.wt) by gavage tube for 7, 9, 12, 14 and 21 days of pregnancy. The acetylcholine level represented significant decrease (P ≤ 0.05) in treated animals in comparison with control groups, while the dopamine level recorded significant increase (P ≤ 0.05) when compare with control groups.