Non- Hodgkin's Lymphoma; Epidemiology and Presentation

Abstract

Background: The non-Hodgkin lymphomas (NHL) of childhood are a diverse collection of diseasesoriginating in the cells and organs of immune system.Objectives: To determine epidemiology and clinicopathological presentations of children with NHLadmitted to Child's Central Teaching Hospital.Methods: A retrospective study was done from 1st of January 2004 to the 31st of December 2009; thepatients with newly diagnosed NHL, age less than 15 years, who were admitted to thepediatric oncology unit in the Child’s Central Teaching Hospital.Results: The total number of patients was 84; the mean age at diagnosis was 6.3years, with a male tofemale ratio of 2:1. Most of patients were presented in stage III&IV (88%).Most commonpresenting features were abdominal distension or a mass in 51%.Burkitt lymphoma andBurkitt like lymphoma were the most common histological subtype (58.33%).Conclusions: The majority of cases were between 5-9 year age group, and the mean age atpresentation was 6.3 years old, with a male to female ratio of 2:1. The most commonpresenting site was the abdomen. The majority of cases were fallen in advanced stages(III&IV). Histopathologically Burkitt's lymphoma was the commonest subtype.