Cutaneous manifestation among patients with β- thalassemia major


Background: Dermatological manifestations among β thalassemia major patients includingskin changes as well as nail, hair, oral mucosa changes and leg ulcer were reported amongthese patients, either due to the hemolytic process of the disease itself or as a sequel oftherapeutic effect taxes of blood transfusion and iron overload complication. In Kurdistanthere is no study has yet investigated the common dermatologic problems that coexist withβ-thalassemia major.Objectives: The purpose of this study was to determine the commonly seen dermatologicproblems in patients with β-thalassemia major.Patients and Method: A descriptive cross sectional study performed at Erbil Thalassemiacenter, the study was conducted among 176 patients over a period extended from April, 2013to January, 2014. They were assessed for cutaneous manifestation with clinical importance ofstatic laboratory tests.Results: All patients enrolled in this study had at least one cutaneous manifestation. Thedisorders are in decreasing order of frequency was pallor, xerosis, jaundice, bronze skin,hyperpigmentation and the least frequent was vitiligo. Most of the of the findings (31.8%)were between (10-15) years age group. The mean age of patients, the mean duration of bloodtransfusion and the mean of serum ferritin level among patients with xerosis, pallor,hyperpigmentation and jaunduce was higher and was statistically significant (p<0.05) alsothere was a significant association between HCV positive and patients with xerosis,hyperpigmentation and jaundice (p<0.05).Conclusion: The cutaneous disorders are common among beta thalasemia patients, pallor,xerosis and jaundice were the common skin changes, while white streak (leukonychia)andgingivitis are the most common nail and oral mucoasa changes respectivly. Xerosis iscommon in patients recieving desferoxamine, serum ferritin level was higher in patients withxerosis,hyperpigmentation and jaundice.