Cytokines profiling as prognostic markers in newly diagnosed acute myeloid leukemia


BACKGROUND: Acute myeloid leukemia (AML) is a common acute leukemia in adult. Recent studieshave shown that cytokine systems influence leukemic cell biology and clinical investigations. Amongvarious cytokines, interleukin‑6 and interleukin‑10 (IL‑6 and IL‑10) participate an essential functionin progression of the disease.OBJECTIVE: The aim of this study is to quantify of IL‑6 and IL‑10 levels in AML patients who arenewly diagnosed and evaluate lipid profile to assess the relationship between lipid profile level andbody mass index (BMI) in myeloid leukemic patients.MATERIALS AND METHODS: Samples were collected from 45 patients with AML from AL‑YarmoukTeaching Hospital in addition to another 45 healthy individuals were served as a control group duringa period from October 2015 to October 2016. Patients ages ranged from 40 to 60 years. IL‑6 andIL‑10 were measured in all patients before any treatments and compared with control group.RESULTS: There was an increase in age, white blood cell, and hemoglobin in AML patients ascompared to control, but it was not significant. There was a significant increase in neutrophils andlymphocyte count, (P = 0.001). Furthermore, there was an increase in BMI, fasting blood sugar,and lipid profile except high‑density lipoprotein cholesterol for AML patients as compared to control,but it was not significant. There was a significant increase in serum IL‑6 and IL‑10 for AML patientscompared to controls (P = 0.001).CONCLUSIONS: The present study refers that AML patients were associated with high concentrationof IL‑6 and IL‑10 in comparing to the control group.