Clinicohematological profile of patients with peripheral blood cytopenias in clinical practice

Abstract

BACKGROUND: In clinical practice, the cytopenias may result from relatively benign causes suchas viral infections and Vitamin B12/folic acid deficiency to more sinister causes such as bonemarrow failure. In this study, we looked into the clinicohematological profile and etiological factorsof bicytopenia and pancytopenia.OBJECTIVES: To study the etiology and clinicohematological profile in patients of peripheral bloodcytopenias.MATERIALS AND METHODS: This was a cross‑sectional study conducted at a tertiary care hospitalover a period of 1 year. Cytopenias were defined as pancytopenia when there was simultaneouspresence of hemoglobin <10 g/dL, total leukocyte count <4000/dL, and platelets < 100000/dL or asbicytopenia when two of the three blood cell lines were depressed. All patients who presented withpancytopenia and bicytopenia were included, and their clinicohematological profile was recorded.RESULTS: A total of 204 patients (103 males and 101 females) were diagnosed to have cytopenias.Pancytopenia was observed in 69/204 and bicytopenia was seen in 135/204 cases. The various causesof cytopenias included infections (n = 126 [61.76%]), megaloblastic anemia (MA) (n = 48 [23.52%]),drugs (n = 12 [5.8%]), hypersplenism (n = 8 [3.9%]), bone marrow failure syndromes such as aplasticanemia and myelodysplastic syndrome (n = 7 [3.4%]) and leukemias (n = 3 [1.4%]). We found asignificant association between MA and pancytopenia (odds ratio [OR] = 2.47, P < 0.05) and alsobetween infections and bicytopenia (OR = 5.8, P < 0.05).CONCLUSION: The present study concluded that infections and MA are the most common cause ofbicytopenia and pancytopenia, respectively. The more serious disorders affecting the bone marrowconstitute only <5% of all cases of cytopenias.