Relation Between Aerobic Bacteria, IFN-γ, TNF-α and Miscarriage in Sample of Iraqi Women


Pregnancy is one of the cases that lead to immune compression, therefore thewomen are exposed to different types of infections and may sequel to miscarriage.Toxoplasma gondii and urinary tract infection (UTI) are the most prevalentinfectious agents in human and have a worldwide distribution. IFN-γ and TNF-α arepro inflammatory cytokine play important role in miscarriage. This study focuses onthe determination, type of aerobic bacteria , concentration of IFN-γ and TNF-αamong (75) abortive women and their relation with miscarriages . The resultsindicated that S.aures was the most prevalence bacteria isolated from abortedwomen infected with UTI or compensation with toxoplasmosis. and among thesubjected women, the significant increases of IFN-γ concentration in serum acrossall groups involved in this study especially that infected with toxoplasmosis(74.84 ±0.44 and 66.81 ± 0.74) pg/ml compared to control (25.60 ± 1.10) pg/ml whereas nosignificant alteration has occurred to TNF-α concentration in all groups (2.26 ± 0.05, 3.32 ± 1.22 and 2.12 ± 0.06 ) ng/ml respectively compared to the control (2.11 ±0.89) ng/ml, and when analyzed the results according to gestational age, all abortivewomen in different trimesters showed significant rises in the concentration of IFN- γ(51.58 ± 3.32, 48.95 ± 3.50 and 48.71 ± 4.84 ) pg/ml.