Radiochemical Evaluation of Iminodiacetate Hepatobility Radiopharmaceuticals

Abstract

Simple and rapid chromatography systems were used to test the radiochemical purity of available 99mTc hepatobiliary iminodiacetate radiopharmaceuticals. A rapid miniaturized chromatography system consisting of Gelman ( ITLC-SA )and 20% NaCl was used to evaluate free pertechnetate and Gelman(ITLC-SG)and distilled water to evaluate hydrolyzed 99mTc (Tc-HR). Results indicated that minimal radiopharmaceuti--cal breakdown occurred in all agents tested within 5 hr post formulation .At 8 hr after preparation, some breakdown was observed in specific IDA radiopharmaceuticals as evidenced by increasing pertechnetate levels . Those systems which were selected which gave no oxidation by products. Greater radiopharmaceutical instability was observed at 24hr post formation 99mTc-HR levels remained relatively low (5%) for IDA tests were done with equipment normally available in Nuclear Medical Departments.