Abstract

Toxoplasma gondii is an opportunistic protozoan in immunocompromised patients and the reactivation of a latent infection could cause severe influence. This study aimed to investigate the chemotherapy effect on the levels of T. gondii immunoglobulins IgG, Interleukins (IL) IL-6, IL-12 and IL-23 in women with breast cancer. In this study, 190 women were enrolled (100 samples were taken from outpatient clinics as control groups and 90 samples of women with breast cancer who attended to Oncology Teaching Hospital in Medical City Hospital in Baghdad from different Governorates in Iraq). All serum samples were tested for T. gondii immunoglobulins IgG antibodies, IL-6, IL-12, and IL-23 levels using ELISA technique. The results showed that the highest mean titers of IgG and IL-23 were in untreated women with breast cancer infected with Toxoplasmosis (168.15 ± 13.53 IU/mL, 258.67 ± 17.05 pg/mL) respectively, while the highest mean titers of IL-12 were in treated women with breast cancer infected with Toxoplasmosis (23.84±0.05 pg/mL), while the highest mean titers of IL-6 were in untreated women with breast cancer infected with Toxoplasmosis (6.551 ± 0.35 pg/mL). The results of this study reveal that the Toxoplasmosis antibody and Cytokines status of women with breast cancer could be affected by the chemotherapy thus, the Toxoplasmosis antibody and Cytokines status should be known before, during and after chemotherapy.

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The article was added to IASJ on 2019-09-24

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