ANEW METHOD FOR ESTIMATION MEBENDAZOLE IN ITS PHARMACEUTICAL PREPARATIONS AND IN CAMEL URINE

Abstract

A simple, accurate and rapid spectrophotometric method has been developed for the estimationof mebendazole in pure, pharmaceutical formulations and camel urine. The method is based onthe reaction of mebendazole with 1-fluoro 2, 4-dinitrobenzene to produce orange-yellow coloredcomplex having maximum absorption at 494 nm. Beeˈs law was obeyed over the concentrationrange of 20-280μg/ml,with molar absorptivity of 3.32x104 l/mol.cm. The present method isconsidered to be simple because it does not need heating, hydrolysis and solvent extraction steps.The proposed method has been successfully applied for the determination of mebendazole inpure ,pharmaceutical formulations and in camel urine