Abstract

This study was designed to evaluate the protective effect of CoQ10 and DHEA and theircombination on norfloxacin induced embryotoxicity and teratogenicity in pregnant female ratsand their fetuses. Twenty pregnant rats were divided equally into 5 groups, 4 animals each groupas following: Control group (G1): 4 normal pregnant female received orally DMSO0.5ml/animal/day from 5th - 19th day of gestation, first treated group (T1): 4 normal pregnantfemale received orally 400 mg/kg norfloxacin once daily, second treated group (T2): 4 normalpregnant female received orally 400 mg/kg norfloxacin once daily and after 1hours injected dailywith CoQ10 200 mg/kg IP, third treated group (T3): 4 normal pregnant female received orally400 mg/kg norfloxacin once daily and after 1hours injected daily with DHEA 25 mg/kg IP, andfourth treated group (T4): 4 normal pregnant female received orally 400 mg/kg norfloxacin oncedaily and after 1hours injected daily with a combination of CoQ10 200 mg/kg and DHEA 25mg/kg IP for the same period. Norfloxacin was administered by oral gavages as a single dose.All dams were sacrificed at 20th day of gestation and their fetuses were collected and subjected tomorphological and skeletal examinations. The obtained results showed that exposure tonorfloxacin in pregnant female rats during gestational period from 5th -19th day demonstrated asignificant increased (P≤ 0.05) in resorbed and stillbirth fetuses (dead fetuses at birth)

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The article was added to IASJ on 2019-10-10

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