The Endoglin (CD105) Expression as a Marker of Tumour Vasculature in Urinary Bladder Tumours of Iraqi patients

Abstract

The Endoglin CD105 is a good marker for metastatic in solid tumors . It has a role in angiogenesis process which mediates blood vessels formation. The aim of this study to evaluate CD105 immunoexpressions in bladder tumors, and to determine its relation with clinico-pathological grades in patients with UBC . The study included 50 biopsies from patients with urinary bladder carcinoma (UBC) and 15- benign bladder biopsies from patients with other bladder disorders rather than cancer (UBD). CD105 immunostaining was assessed using Envision method . Immunohistochemical (IHC) studying showed that (CD105) proteins were significantly high expressed in UBC compared with UBD patients (80% vs. 33.3 % ; p≤ 0.01) , and there was significant difference in the positive IHC results of this protein in correlation to clinico-pathological grades in UBC patients (p≤ 0.01) . we conclude that CD105 IHC expressionin bladder cancer may be consider as prognostic marker .