Immunohistochemical Expression of Cyclin D1 in Urothelial Carcinoma of Urinary Bladder


ABSTRACT:BACKGROUND: Transitional cell carcinoma is the most common cancer in urinary bladder. Bladder carcinoma is the 5th from the most common ten cancersin Iraq, It is the 2nd in males and the 10th in females according to Iraqi Cancer Registry. It is the 4th most common cancer in inmales, 8thin females in the USA.OBJECTIVE: To evaluate the immunohistochemical expression of cyclin D1 in transitional cell carcinoma of urinary bladder and its role in predicting type, grade, stage, progression and prognosis of the tumor.MATERIALS AND METHODS:This is retrospective study of 40 bladder biopsy (formalin fixed ,paraffin embedded). Two sections of 5 μmthickness were taken from each block, the first was stained with H&E, the 2nd was stained immunohistochemically for cyclin D1.RESULTS: The majority of cases were high grade papillary urothelial carcinoma stage T1 .Nine of cases were score 0 of 4 , six of cases were score 1, three of cases were score 2 ,eleven of cases were score 3,eleven of cases were score 4.CONCLUSION: There was no statistical significant correlation between cyclinD1 immunohistochemical expression and tumor stage, grade and type.KEYWORDS: cyclinD1 expression, Transitional cell carcinoma