Effect of Magnesium Sulfate on Hemodynamic Response to CO2 Pneumoperitoneum in Patients Undergoing Laparoscopic Cholecystectomy


BACKGROUND:Pneumoperitoneum with CO2 insufflation is used during laparoscopic cholecystectomy to facilitatesurgical access as it is a minimally invasive procedure, and despite its benefits when compared to theopen cholecystectomy, it is known that pneumoperitoneum has some adverse physiological effectsincluding an abrupt increase in the arterial blood pressure and an increase in the heart rate due toincreased catecholamines release.OBJECTIVE:To investigate the effect of magnesium sulfate on attenuating the hemodynamic response to carbondioxide pneumoperitoneum in patients undergoing laparoscopic cholecystectomy.PATIENTS AND METHODS:This double blind prospective study was conducted in Rizgari Teaching Hospital in Erbil/Iraq on 60patients whose ages ranges between (20-45) years to assess the effectiveness of magnesium sulfate inattenuating the hemodynamic response to cholecystectomy, after dividing the patients into twogroups: group I (magnesium group) and group II control group.RESULTS:The increase in systolic blood pressure, diastolic blood pressure, mean arterial blood pressure andheart rate readings were less in group I (Magnesium group) when compared to group II (controlgroup) with a statistically significant difference (p < 0.05).CONCLUSION:It can be concluded that magnesium sulfate attenuates the hemodynamic response topneumoperitoneum in laparoscopic cholecystectomy.KEYWORDS: Magnesium sulfate, Laparoscopic cholecystectomy,