Evaluation of Thyroid Autoimmunity's in Women with Polycystic Ovary Syndrome

Abstract

ABSTRACT: Background Polycystic Ovary Syndrome - PCOS- is the most common endocrine disease that affects women of reproductive age. The Aim is to assess the levels of thyroid antibodies in women with PCOS in Iraq, and to learning the link between PCOS and thyroid hormones. Patients & Methods: Two study groups have been investigated; the first group consists of one hundred and five infertile women with PCOS. The second group is healthy control which consists of forty six healthy fertile women. Hormonal analysis was performed by using a ready kit in accordance with the manufacturer's instruction (Biomerieux SA Etoile-France) and minividas full automated system (Triiodothyronine) .Thyroxine is performed by a one-step enzyme immunoassay competition method with a final fluorescent detection (ELIFA) (Enzymelinked immunoflourecent assay) and minividas full automated system (Biomerieux SA Etoile- France). Thyroid stimulation hormones , anti -thyroid peroxidase autoantibodies ,anti-TPO and anti -thyroglobulin antibodies Tg is performed by means of immunoassay sandwich with a final fluorescent detection (ELIFA) method with the use of a ready kit in accordance to the manufacturer's instruction (Biomerieux) and MiniVidas Full automated system (Biomerieux). The Results: It was found a highly significant difference (p< 0.01) between the thyroid stimulation hormone means (7.03± 13.45) μIU/ml of the infertile women with a mean of (3.51±4.43) μIU/ml of the control group, while the mean of Triiodothyronine and Thyroxine was found a slightly significant difference (0.05>p>0.1),). A positive result was found for thyroid peroxidase antibody (TPO-Abs)in infertile women (19.95 1± 39.53) IU/ml was higher than that of the control (4.82±4.7 ) IU/ml; anti-Tg autoantibodies in infertile women were (31.31±65.86) IU/ml compared to control (11.75±27.30) IU/ml with a significant difference(P=0.001).