Biological Role and Significance of Copper in Diarrhea

Abstract

The study was enrolled on (121) subjects, (71) of them with diarrhea and (50) healthy control at ages ranging from 2 month to 5 years. Venous bloods were collected from all patients for the detection of serum copper concentration by spectrophotometric method. It was found that the frequency of lowest concentration of copper 31 (43.7%) in diarrheal cases while the control groups low concentration was only in one case and the percent (2%),these results highly significant (p <0.05).About 23(1.1%) of the dehydrated cases had low serum copper vs. 8(30.8%) of the non- dehydrated, this relation was statistically not significant but important to measure the presence of signs of dehydration ,lows of weight as early detection of the severity or morbidity of diarrhea in children with signs of copper deficiency. Among our patients the mean of copper concentration was (15.3 ±5.8)in male compared with the control group (17.1±3.98) had no significant differences (p>0.05).While in female (14.3 ±5.4) compared with the control group (20.5 ±3.3) statistically significant (p<0.05).The gender differences are due to gender-specific differences in copper trafficking rather than differences in dietary intake. Human body has an elaborate system for managing and regulating the amount of key trace metals. The Correlation between the copper level and hematological status shows that low copper level with low status, also the electrolyte imbalance in diarrheal children with lower (Na+, K+ ,Cl-) concentrations.