A Comparison between the Acute Effects of Coxis on renal function with that of diclofenac Sodium in patients with rheumatological disorders


The aim of this study was identify the effect of (coxibs) on renal function in comparison to the traditional (NSAIDs) to provide more insight on this issue. Particular emphasis has been paid to the possible acute renal toxicities such as acute decline in renal function, hyperkalaemia, hypertension and sodium and water retension, the study was conducted during the period from (February –August) 2018 , Rheumatological out-patient clinic in Ibn-Sina Teaching Hospital in Mosul. patients and methods : Eighty patients with different rheumatological disorders who have no history of pre-existing renal disease. They were divided into 2 groups: Group A (40 patients): Treated with diclofenac sodium and Group B (40 patients): Who were treated with celeecoxib. Twenty healthy subjects, group C were taken as a control group. They have all undergone clinical examination including measurement of their body weights and blood pressure at the start of the study and repeated a month later.