Correlation Study Between Alanine Aminopeptidase (AAP) And Adiponectin For Patients With Hemodialysis And Other Biochemical Paramrters

Abstract

Chronic Renal Failure (CRF) is a gradual loss of Kidney function, therefore the patient needs a"long" treatment that is a substitute for kidneys. The study included (70) samples of the serum ofchronic renal failure of both sexes, aged (25-70) years. The samples were divided into two groups,the first group is of (35) samples before dialysis. The second group is of (35) samples after dialysis,as well as (30) samples of natural persons (healthy) as a comparison group, aged (25-65) years.The results showed a significant increase (P<0.001) in general in the enzyme Alanine aminopeptidase(AAP) in the serum of chronic renal failure patients (116.0 ± 3.4) U/L while the efficacy rate is(105.5 ± 3.4 U/L in healthy persons.It was also observed during the study that the concentration of adiponectin, malondialdehyde,urea, and uric acid showed a "significant" increase (P <0.001) compared to healthy persons. (P <0.001)with peroxynitrite concentration compared to healthy persons. There was also no significant difference(P> 0.05) in BMI compared to healthy persons.The study aimed to estimate the effectiveness of the Alanine aminopeptidase (AAP) enzyme inthe serums of patients with Chronic Renal Failure, as well as the estimation of some biochemicalvariables such as adiponectin (ADP), antioxidants (malondialdehyde, peroxynitrite), as well as urea,creatinine, uric acid, Body Mass Index (BMI)