Genetic and environmental study of blood pressure parameters in Western region of Iraq

Abstract

Genetic variation acts a significant role in incidence of blood pressure. Genetic involvement in blood pressure can be delineated by estimating heritability using family-based data of full or half sibs, but such an approach is not practical for blood pressure since it requires a large pedigree based data. On the other hand, heritability of blood pressure parameters was estimated using parent-offspring regression. Therefore, the purpose of the present study is to investigate genetic influences on intra-individual variation of some blood pressure parameters, by performing heritability analysis on an Iraqi population (Anbar province). In this study, 61 families were included. The total number of studied population was 274 individuals, consisting of 87 parents and 187 siblings. Most of the parents included in the study were in their 5th and 6th decade of life, about half of them fall under the “overweight” category according to their waist circumference (WC) values, and body mass index (BMI) were variable. Heritability of blood pressure parameters was estimated using parent-offspring regression. Heritabilities of blood pressure parameters adjusted to age, sex, body mass index and circumference were estimated to be 0.33± 0.08, 0.36±0.10, 0.29±0.05 and 0.62± 0.10 for systolic(SBP), diastolic(DBP), mean blood pressure(MBP) and pulse pressure (PP), respectively. Analysis of the data suggest that the age, body mass index, and waist circumference have significant effect (P<0.05) on diastolic blood pressure,systolic blood pressure, pulse pressure , and mean of blood pressure, whereas sex has no effect.The finding of modest heritability indicates the significant role of non-genetic factors affecting systolic, diastolic and mean blood pressure, whereas genetic variation plays a substantial role in the pulse pressure.