Correlation of Prostaglandin-D2 with disease severity of adult asthma


Background: Prostaglandin D2 (PGD2) is a lipid mediator appeared as a powerful activator that regulates the T-helper2 (TH2) and Type-2 innate lymphoid cells (ILC2), and functions as diagnostic marker and it has probabletherapeutic targets forasthma. Objectives: To define the role of Prostaglandin D2 biomarkers in disease severity, and to forecast disease risk and progression.Patients and methods:Acase control study was conducted onForty fourIraqi asthmatic patients and 44 apparently healthycontrols who wereage and sex matched. Four ml of blood samples was takenfrom the study groups for the detection PGD2 using ELISA.Results:The serum level of PGD2 was almost convergent between cases and control group (median= 36.5pg/mland 35.1pg/mlrespectively).Thehigh medianserumconcentration of PGD2 showed a strong statisticallysignificant association withtheseverity of asthmatic patients (39.8 pg/ml) in severe casescompared to (30.84 pg/ml) in moderate cases (P value =0.005). The median concentrationof serum PGD2 revealed a higher level in abnormal eosinophil, monocytes and total IgE (42 pg/ml), (48.9 pg/ml) and (38.5 pg/ml) respectively than the median concentrationof normal counts. Conclusions: Measuring serum PGD2 in asthmatics is crucial to predict disease susceptibility, severity and disease control.