Study the Physiological Effects of Finasteride (Prostacare) on some Reproductive Parameters in Male Rats.(Rattus- Rattus)

Abstract

This study was conducted in the veterinary medicine college in basrah university animal house and aimed to investigate the effect of finasteride (prostacare) on malesome parameters reproductive system in albino male rats (Rattua-Rattus). Thirty six mature male rats with body weight 200-210 g and age 8 weeks were randomly divided into three groups (12 animal each group). The first group was considered as control group and treated orally normal salin (0.9%N.S)during the experimental 30 days , the second group was treated finasteride(0.016mg/kg of body weigt oraiiy during the experimental(30)days.and the third group was administrated finasteride(0.032mglkg of body weigt orally during the experimental 30 days. The results showed a significant decrease in the sperm count ,sperm motility ,live sperm and increase in dead sperm percentage as well as a significant decrease in the level of reproductive hormones (testosterone, LH and FSH) in treated group with finasteride compared with control group , from this study it was concluded that the finasteride has undesired physiological effects on fertility in albino male rats (Rattus-Rattus).