Evaluation the activity of serum prolidase in patients with renal failure


Current study conducted on serum of 64 persons 33 of them are with renal failureand 31apparently healthy as control group their age ranged between 22 - 55 years forthe period between 22 / 11 / 2019 to 5 / 2 / 2020.The parameters that measured are prolidase enzyme activity and concentrationof Malondialdehyde-MDA, Glutathione-GSH and Urea in serum of patients and controlgroups by colorimetric methods.The present study results show a significant (P ≤ 0.05) decrease in prolidaseenzyme activity in patients serum as compared to control with a significant (P ≤0.05) decrease in Glutathione-GSH mean in patients serum as compared to control,while Malondialdehyde-MDA and Urea levels show a significant (P ≤ 0.05) increase inpatients serum as compared to control.The correlation coefficient between prolidase activity and GSH, MDA and urea,the results indicate that the correlation was significant positive correlation betweenprolidase and GSH (R=0.483), while the correlation with other parameters (MDAand urea) were non-significant, in which the correlation was positive with urea andnegative with MDA.