Role of leptin and inhibin B in infertile males with metabolic syndrome

Abstract

Harm of metabolic syndrome (MS) on male infertility is mostly attributed to the various problems related withoverweight such as scrotal temperature, variation of serum testosterone levels or dyslipidemia. The current study wasdesigned to determine the correlation of leptin with inhibin B and sex hormones in infertile men with metabolicsyndrome. Forty five infertile male patients with a complete history and clinical examination were taken from the periodfrom January to July 2017 with thirty fertile apparently healthy male volunteers. Blood samples were drawn from allpatients subjects and healthy control in fasting state to measure the biochemical parameters which included fastingglucose levels (FBG), triglyceride (TG), high density lipoprotein HDL-c, concentrations. Also, follical-stimulattinghormone (FSH), luteinizing hormone (LH), total testosterone (tT) levels were estimated, while the levels of seruminhibin B and leptin were estimated. Additionally body mass index (BMI), waist circumference (WC) and blood pressure(BP) were recorded to all subjects. The results revealed a significant increase in the level of BMI, WC, SBP, DBP, FBG,triglyceride, high density lipoprotein level in the patients group when compared with the control group. Beside that, thelevels of FSH, LH, tT, leptin and inhibin B were significantly highly different when comparing the patients group withthe control group. Furthermore, a highly significant coefficients of correlation was observed between the leptin and FSH,LH, tT, inhibin B (r = -0.46, -0.38, 0.28, -0.29) respectively. This study suggests that increasing the levels of leptinassociated with infertility in males with metabolic syndrome and the imbalance in reproductive hormone correlated withhyperliptinemia.