Endothelin Level and Its Correlation with Uric Acid in Type 2 Diabetic Multiuse Patients

Abstract

This research aims to find the direct linkage among the Uric acid rates with Endothelin (ET-1),which is considered the indication of endothelial dysfunction or endothelial damage in patientswith T2-DM. This study, included 96 patients with T2-DM and 96 controls, the mean ageranged (56.73 ± 9.14), (56.42 ± 8.74) respectively. Results showed a highly significant increasein Endothelin (ET-1) levels, uric acid, urea, and systolic blood pressure (SBP) was observed ascompared with control group, while Diastolic blood pressure (DBP) and body mass (BMI) werenot substantially increased. Additionally, significant positive correlation was found betweenET-1 with uric acid, urea, SBP, DBP in patients with T2-DM (p < 0.05). Finally, elevated uricacid levels in older people who have chronic blood pressure are one of the factors influencingthe increase release of ET-1, thus the development of cardiovascular disease.