Serum levels of Interleukin 6 and Homocysteine in Type 2 Diabetic Patients with renal failure complication

Abstract

ackground: Cardiovascular diseases are more common among type 2 diabeticpatients than healthy subjects without a family history of diabetes. Seruminterleukin-6 (IL-6) and homocysteine (Hcy) levels are markers of endothelialdysfunction and cardiovascular disease.Aim: this study demonstrated to evaluate levels of IL-6, Hcy and their associationwith cardiovascular risk in type 2 diabetic patients with renal failure complication.Material & Methods: The circulating IL-6 and Hcy levels were measured in 45 type2 diabetic patients and 25 control subjects without a known family history of diabetes.The BIOSOURCE IL-6 ELISA kit used to measure IL- 6, high performance liquidchromatography HPLC technique used to measure serum Homocystein, andenzymatic methods are used for blood suger, urea, creatinine, and lipid profilemeasurements.Results: A significant differences were found in serum levels of IL6 and Hcybetween the two groups diabetic and healthy control (p>0.05). IL6 levels correlatedsignificantly with Hcy (p=0.02), hemoglobin A1C (p=0.03), and serum Hcy correlatedsignificantly with HbA1C (p=0.03) levels in patients with type 2diabetes mellitus.Conclusion: These results suggest that serum IL-6 and Hcy levels do not directlycontribute to the development of endothelial dysfunction and cardiovascular riskfactors in type 2 diabetic patients with renal failure complication.