Evaluation of Oxidative Stress and LeptinLevel in Samples of Iraqi Obese Women

Abstract

The aim of this study is to investigate oxidative stress and leptinlevel in obesewomen. Fifty obese women with BMI value of ≥ 30.0 kg/m2 and thirty healthywomen with BMI<24.9 kg/m2 were involved in the study during their attendance atGastroenterology and Liver Hospital/ Medical city in Baghdad province fromOctober 2018 to February 2019. The age range for all women was 30-50 years.Blood samples were collected from each participant for the evaluation of the levelsof leptin hormone, Super Oxide Dismutase (SOD), and Malondialdehyde (MDA).The results of BMI, leptin hormone, MDA and SOD showed highly significantincrease (P<0.01) in obese women in comparison with the control group.Results: The results show that BMI value were significantly higher (P<0.01) inobese women (41.90 ± 0.87kg/m2) in comparison with the control (23.58 ±0.28kg/m2). The level of leptin hormone was significantly higher(P<0.01) in obesewomen (1444.00 ± 10.67pg/ml) in comparison with the control (932.26 ±25.92pg/ml). Also, MDA level was significantly higher(P<0.01) in obese women(6.81 ± 0.29mg/dl) in comparison with the control (4.53 ± 0.44) mg/dl. The level ofSOD was significantly higher(P<0.01) in obese women (15.67 ± 1.42mg/dl) incomparison with the control group (3.75 ± 0.60mg/dl).Conclusions: Obesity is detected by the level of leptin Hormone; leptin is regardedas a good parameter for monitoring obesity,showing a high increasewith increasingBMI.Theincrease in obesity causes oxidant stress and formation of MDA that isconsidered as a major risk factor in obesity,where adecrease in antioxidants was alsorecorded.

Keywords

Obesity, BMI, Leptin, MDA, SOD.