Role of cytokines in pathogenesis of H. pylori induced gastric mucosal inflammation


Helicobacter pylori gastritis is characterized by colonize the stomach and induce strong, specific local and systemic humoral and cell-mediated immunity. The aim of this study was to evaluate the level of several cytokines and their role in the pathogenesis of H. pylori gastritis and whether H. pylori stimulate the release of these cytokines. The levels of TH1 (IFN-γ and TNF-α) and TH2 (IL-4, IL-6 and IL-10) cytokines, as well as, inflammatory cytokines (IL-1α and IL-8) were determined. Most of the investigated cytokines (IL-1α, IL-6, IL-8, IL-10, IFN-γ, TNF-α and GM-CSF) showed a significantly increased level in the sera of H. pylori gastric patients as compared to subjects (control) with no infection which showed normal serum interleukin levels. While IL-10 showed significant decrease when compared to subjects. These results conclude the pro-inflammatory cytokines have a central role in the pathogenesis of H. pylori-induced mucosal inflammation.