Relationship of Platelet Lymphocyte Ratio and Neutrophil Monocyte Ratio with Disease Severity of Knee Osteoarthritis


BACKGROUND:Osteoarthritis is a low-grade systemic inflammatory and degenerative disease in which manyinflammatory mediators are known to be elevated in the peripheral blood. Platelet lymphocyte ratioand neutrophil monocyte ratio are novel markers in many systemic inflammatory disorders. Studiesare limited on its link with knee osteoarthritis severity.OBJECTIVE:To evaluate the relationship of PLR and NMR with the Knee Osteoarthritis (KOA) severityPATIENTS AND METHODS:A total of 200 patients with KOA were diagnosed according to the American College ofRheumatology clinical criteria 2016. Demographic and clinical characteristics data were recorded.X-ray was taken for both knee joints in standing and lateral position view. Blood samples werecollected PLR and NMR were calculated.RESULTS:Mean age was 62.3 ± 8.7 years, female to male ratio as 1.5:1. Mean BMI was 29.2 ± 6.3 kg/m2, andknee OA duration 9.8 ± 7.8 years. Age, knee OA duration, menopausal duration, total WOMACscore and menopause were significantly correlated with increase knee OA severity (p<0,001),(p<0,001), (p<0,001), and (p=0,003) respectively while marital status was significantly inverselycorrelated with knee OA severity (P<0.001). Knee OA duration and total WOMAC score were theonly independent predictors of knee OA severity (p<0.001), (p<0.001) respectively. PLR and NMRwere not correlated with severity of KOA.CONCLUSION:PLR and NMR had no significant correlation with the KOA severity