Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Fenoprofen Hydrazone Derivatives

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) have become important as an analgesic, antipyretic and anti-inflammatory medications throughout the world. In 2006, NSAIDs market in the US alone was valued at $3.2 billion, and it was probably to reach $4.6 billion by 2013. NSAID use can cause a range of serious adverse effects including gastrointestinal complications, cardiovascular problems, renal failure and hypersensitivity reactions. In order to reduce the side effects and improve the anti-inflammatory activity, new derivatives of Fenoprofen were synthesized which contain hydrazones moiety. The compounds then evaluated for their anti-inflammatory activity by means of egg white induced paw edema method. All the synthesized target compounds were characterized by FT-IR spectroscopy, 1HNMR analysis. The synthesis of the target compounds(H1-H4) was accomplished by multistep reaction procedures. The synthesized target compounds showed an activity in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Fenoprofen) except for compound H3 which shows anti-inflammatory activity higher than Fenoprofen