Hypotensive Action of Pomegranate Seed Extract and Zinc Chloride in Hypertensive Rats

Abstract

This study investigated the effects of pomegranate seed extract and supplementary zinc chloride (ZnCl2) on Dexamethasone (DEX) and NaCl induced hypertension in rats. For this purpose, female albino rats were divided into five groups: control and four DEX and NaCl induced hypertensive rats. The animals were given pomegranate seed extract, ZnCl2, or a combination of both for two weeks. Our results show a significant decrease in systolic blood pressure (SBP) in each of the treated groups, except the combination group. DEX and NaCl combination significantly decreased the total body weight in rats. The body weight was not changed with pomegranate seed extract or ZnCl2 administration. Besides WBC, RBC, HGB, HCT, and PLTs levels were not altered. There were no significant differences in the levels of serum K+, Ca2+, and Cl- ions among the treated groups. Nevertheless, the Na+ level in the serum increased significantly in rats of the combination group. Taken together, we conclude that pomegranate seed extract and ZnCl2 consumption can be beneficial for lowering blood pressure in hypertensive patients when consumed separately.